Immunostimulatory DNA ameliorates experimental and spontaneous murine colitis.

@article{Rachmilewitz2002ImmunostimulatoryDA,
  title={Immunostimulatory DNA ameliorates experimental and spontaneous murine colitis.},
  author={D. Rachmilewitz and F. Karmeli and K. Takabayashi and Tomoko Hayashi and L. Leider-Trejo and Jongdae Lee and L. Leoni and E. Raz},
  journal={Gastroenterology},
  year={2002},
  volume={122 5},
  pages={
          1428-41
        }
}
BACKGROUND & AIMS Impaired mucosal barrier, cytokine imbalance, and dysregulated CD4(+) T cells play important roles in the pathogenesis of experimental colitis and human inflammatory bowel disease. Immunostimulatory DNA sequences (ISS-DNA) and their synthetic oligonucleotide analogs (ISS-ODNs) are derived from bacterial DNA, are potent activators of innate immunity at systemic and mucosal sites, and can rescue cells from death inflicted by different agents. We hypothesized that these combined… Expand
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