Immunostimulation of dendritic cells by cationic liposomes.

  title={Immunostimulation of dendritic cells by cationic liposomes.},
  author={Dileep Padinjarae Vangasseri and Zhengrong Cui and Weihsu Claire Chen and David A. Hokey and Louis D. Falo and Leaf Huang},
  journal={Molecular membrane biology},
  volume={23 5},
A nano-aggregate liposome-polycation-DNA (LPD), composed of a cationic lipid, protamine and plasmid DNA was found to effectively deliver a human papillomavirus (HPV)-E7 epitope antigen to the antigen presenting cells of the immune system, eliciting enhanced anti-tumor immune responses in mouse models of cervical carcinoma. Both the cationic liposome and plasmid DNA were essential for the full immunostimulation activity of LPD. Interestingly, cationic liposomes alone could stimulate the antigen… CONTINUE READING
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