Immunostimulating hexapeptide from human casein: amino acid sequence, synthesis and biological properties.

@article{Parker1984ImmunostimulatingHF,
  title={Immunostimulating hexapeptide from human casein: amino acid sequence, synthesis and biological properties.},
  author={Fred T. Parker and Dani{\`e}le Migliore-Samour and F E Floc'h and Aurelio Zerial and Georges Werner and Jacqueline Joll{\'e}s and M. Casaretto and Helmut Zahn and Pierre Joll{\`e}s},
  journal={European journal of biochemistry},
  year={1984},
  volume={145 3},
  pages={677-82}
}
A hexapeptide obtained from human casein by enzymatic digestion has been purified, sequenced and synthesized; its structure is: Val-Glu-Pro-Ile-Pro-Tyr. In vitro this hexapeptide stimulates the phagocytosis of opsonized sheep red blood cells by murine peritoneal macrophages. Administered intravenously to adult mice, it enhances the resistance to infection with Klebsiella pneumoniae.