Immunosenescence increases the rate of acceptance of kidney allotransplants in elderly recipients through exhaustion of CD4+ T-cells.

@article{Trzonkowski2010ImmunosenescenceIT,
  title={Immunosenescence increases the rate of acceptance of kidney allotransplants in elderly recipients through exhaustion of CD4+ T-cells.},
  author={Piotr Trzonkowski and Alicja M Debska-Slizien and Magdalena Jankowska and Anna Wardowska and Manuela M Carvalho-Gaspar and Łukasz Hak and Grażyna Moszkowska and Beata Bzoma and Natalie Mills and Kathryn J. Wood and Jolanta M. Myśliwska and Bolesław Rutkowski},
  journal={Mechanisms of ageing and development},
  year={2010},
  volume={131 2},
  pages={96-104}
}
Compromised immunity is the hallmark of ageing. Paradoxically, it may be "an ally" in facilitating acceptance of allogeneic grafts in the elderly. In this retrospective study we looked for biomarkers of immunosenescence that distinguish elderly recipients less prone to reject kidney allografts. Recruited kidney recipients aged > or = 60 or < 60 were… CONTINUE READING