Immunoregulatory role of Ig isotypes. I. Induction of contrasuppressor T cells for contact sensitivity responses by antibodies of the IgM, IgG1, and IgG3 isotypes.

Abstract

A profound state of specific tolerance for the contact sensitivity reaction can be produced by i.v. exposure to hapten on the surface of syngeneic macrophages. When the same haptenated cells are incubated with specific antibody to form cell-bound Ag-antibody complexes, i.v. injection induces immunity rather than tolerance. We observe that such cell-bound Ag… (More)

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@article{Ptak1988ImmunoregulatoryRO, title={Immunoregulatory role of Ig isotypes. I. Induction of contrasuppressor T cells for contact sensitivity responses by antibodies of the IgM, IgG1, and IgG3 isotypes.}, author={Wlodzimierz Ptak and Patrick M. Flood and Charles A. Janeway and Janusz Marcinkiewicz and Douglas R Green}, journal={Journal of immunology}, year={1988}, volume={141 3}, pages={756-64} }