Immunoregulatory gene polymorphisms are associated with ANCA-related vasculitis.

  title={Immunoregulatory gene polymorphisms are associated with ANCA-related vasculitis.},
  author={Marjan C Slot and Milena G Sokolowska and Kim G. M. Savelkouls and Rob G J H Janssen and Jan Damoiseaux and Jan Willem Cohen Tervaert},
  journal={Clinical immunology},
  volume={128 1},
T cell activation is regulated by inhibitory molecules such as PD-1 and CTLA-4, whose expression may be affected by gene polymorphisms. Increased T cell activation is present in patients with ANCA-associated vasculitis (AAV). We investigated two single-nucleotide polymorphisms (SNPs) in PDCD1 and five polymorphisms in CTLA4 in 102 patients with AAV and 188 healthy controls (HC). The distributions of the PD-1.3 and PD-1.5 SNPs, and the distributions of the CTLA4 promoter polymorphisms -1722T/C… CONTINUE READING


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