Immunoregulatory effects of neuropeptides. Stimulation of interleukin-2 production by substance P

@article{Rameshwar1992ImmunoregulatoryEO,
  title={Immunoregulatory effects of neuropeptides. Stimulation of interleukin-2 production by substance P},
  author={P. Rameshwar and P. Gasc{\'o}n and D. Ganea},
  journal={Journal of Neuroimmunology},
  year={1992},
  volume={37},
  pages={65-74}
}
Substance P (SP), a tachykinin neuropeptide, has been previously reported to stimulate T cell proliferation, and SP receptors have been identified on subpopulations of T lymphocytes. The effect of SP on the interleukin-2 (IL-2) production has been investigated by using the murine EL-4.IL-2 and LBRM-T6G T cell lines. SP synergized with phorbol 12-myristate 13-acetate (PMA) in a dose-dependent manner to induce IL-2 production. The generated interleukin was identified as IL-2 by neutralization… Expand
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