Immunoregulatory effects of human dental pulp-derived stem cells on T cells: comparison of transwell co-culture and mixed lymphocyte reaction systems.

@article{Demircan2011ImmunoregulatoryEO,
  title={Immunoregulatory effects of human dental pulp-derived stem cells on T cells: comparison of transwell co-culture and mixed lymphocyte reaction systems.},
  author={Pinar Cetinalp Demircan and Ayla Eker Sariboyaci and Zehra Seda Unal and Gulcin Gacar and Cansu Subaşi and Erdal Karaoz},
  journal={Cytotherapy},
  year={2011},
  volume={13 10},
  pages={
          1205-20
        }
}
BACKGROUND AIMS. Studies performed using human and animal models have indicated the immunoregulatory capability of mesenchymal stromal cells in several lineages. We investigated whether human dental pulp-derived stem cells (hDP-SC) have regulatory effects on phytohemagglutinin (PHA)-activated CD3(+) T cells. We aimed to define the regulatory mechanisms associated with hDP-SC that occur in mixed lymphocyte reaction (MLR) and transwell systems with PHA-CD3(+) T cells and hDP-SC at a ratio of 1:1… CONTINUE READING
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