Immunoregulatory circuits among T-cell sets. I. T-helper cells induce other T-cell sets to exert feedback inhibition

@article{Eardley1978ImmunoregulatoryCA,
  title={Immunoregulatory circuits among T-cell sets. I. T-helper cells induce other T-cell sets to exert feedback inhibition},
  author={Diane D. Eardley and J Hugenberger and L McVay-Boudreau and Fung Win Shen and Richard K. Gershon and Harvey Cantor},
  journal={The Journal of Experimental Medicine},
  year={1978},
  volume={147},
  pages={1106 - 1115}
}
These experiments test the hypothesis that cells carrying the Ly1+23- surface phenotype are programmed exclusively for helper and not suppressive activity regardless of external conditions such as the mode or type of antigen stimulation. To this end, we have stimulated purified populations of Ly1 cells with antigen in vitro using conditions devised to… CONTINUE READING