Immunoregulatory abnormalities in Evans syndrome.

  title={Immunoregulatory abnormalities in Evans syndrome.},
  author={Winfred C. Wang and Henry G. Herrod and C. H. Pui and G J Presbury and Judith A. Wilimas},
  journal={American journal of hematology},
  volume={15 4},
Immune function in six patients with Evans syndrome (Coombs-positive hemolytic anemia and immune thrombocytopenia) was compared to that in seven with chronic ITP. The two groups differed in measurements of T-cell subsets and immunoglobulin production. Evans syndrome patients had decreased T4 (T-helper) (P = 0.025), increased T8 (T-suppressor) (P = 0.008), and a decreased ratio of T4:T8 cells (P = 0.0009) when compared to controls. Results in chronic ITP patients were similar to those in… CONTINUE READING
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