Immunoregulatory T Cells : New Therapeutics for Graft-Versus-Host Disease

  title={Immunoregulatory T Cells : New Therapeutics for Graft-Versus-Host Disease},
  author={Jos{\'e} Laurent Cohen and Aur{\'e}lie Trenado and Douglas Vasey and David Klatzmann and Beno{\^i}t L. Salomon},
CD4 CD25 immunoregulatory T cells play a pivotal role in preventing organ-specific autoimmune diseases and in tolerance induction to allogeneic organ transplants. We investigated whether these cells could also control graft-versus-host disease (GVHD), the main complication after allogeneic hematopoietic stem cell transplantation (HSCT). Here, we show that the few CD4 CD25 T cells naturally present in the transplant regulate GVHD because their removal from the graft dramatically accelerates this… CONTINUE READING
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