Immunoregulation of Th cells by naturally processed peptide antagonists.

  title={Immunoregulation of Th cells by naturally processed peptide antagonists.},
  author={Richard T. Carson and D V Desai and Kate M Vignali and Dario A A Vignali},
  journal={Journal of immunology},
  volume={162 1},
Th cells recognize protein Ags as short peptides bound to MHC class II molecules. Altered peptide ligands can antagonize (inhibit) T cell responses to stimulatory peptides. Peptides generated by APC may contain peptide flanking residues (PFR), which lie outside the minimal binding epitope and can be recognized by the TCR. Our data show that PFR-dependent T cells were found to be potently antagonized by peptides that lack PFR and responded poorly to native protein or the immunogenic epitope… CONTINUE READING


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