Immunoregulation in autoimmune thyroid disease.

  title={Immunoregulation in autoimmune thyroid disease.},
  author={Rich Volpe},
  journal={The New England journal of medicine},
  volume={316 1},
  • Rich Volpe
  • Published 1987 in
    Thyroid : official journal of the American…
We have postulated over many years that autoimmune thyroid diseases (AITD) are disorders of immunoregulation due to antigen specific defect(s) in suppressor (regulatory) T (Ts) lymphocyte function. Despite earlier skepticism, there is recent increased evidence to support this view. Several investigators working with animal models have demonstrated T lymphocyte subsets that are regulatory, i.e., will prevent AITD; conversely, depletion of these cells precipitates the lesion in the experimental… CONTINUE READING