Immunoreceptor tyrosine-based activation motif (ITAM), a unique module linking antigen and Fc receptors to their signaling cascades.

@article{Isakov1997ImmunoreceptorTA,
  title={Immunoreceptor tyrosine-based activation motif (ITAM), a unique module linking antigen and Fc receptors to their signaling cascades.},
  author={Noah Isakov},
  journal={Journal of leukocyte biology},
  year={1997},
  volume={61 1},
  pages={
          6-16
        }
}
  • Noah Isakov
  • Published 1997 in Journal of leukocyte biology
Signal transduction by the T cell and B cell antigen receptors and by receptors for a variety of immunoglobulins' Fc region is strictly dependent on a receptor subunit cytoplasmic module termed immunoreceptor tyrosine-based activation motif (ITAM). This module exists in one or more copies in each of the receptor-associated signal-transducing molecules and it possesses two repeats of the consensus sequence Tyr-X-X-Leu/Ile spaced by six to eight amino acids. Receptor engagement is followed by a… CONTINUE READING
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