Immunoreceptor tyrosine‐based activation motif phosphorylation during engulfment of Neisseria gonorrhoeae by the neutrophil‐restricted CEACAM3 (CD66d) receptor

@article{McCaw2003ImmunoreceptorTA,
  title={Immunoreceptor tyrosine‐based activation motif phosphorylation during engulfment of Neisseria gonorrhoeae by the neutrophil‐restricted CEACAM3 (CD66d) receptor},
  author={S. E. McCaw and J. Schneider and E. Liao and W. Zimmermann and S. Gray-Owen},
  journal={Molecular Microbiology},
  year={2003},
  volume={49}
}
  • S. E. McCaw, J. Schneider, +2 authors S. Gray-Owen
  • Published 2003
  • Medicine, Biology
  • Molecular Microbiology
  • Gonorrhea is characterized by a purulent urethral or cervical discharge consisting primarily of neutrophils associated with Neisseria gonorrhoeae. These interactions are facilitated by gonococcal colony opacity‐associated (Opa) protein binding to host cellular CEACAM receptors. Of these, CEACAM3 is restricted to neutrophils and contains an immunoreceptor tyrosine‐based activation motif (ITAM) reminiscent of that found within certain phagocytic Fc receptors. CEACAM3 was tyrosine phosphorylated… CONTINUE READING
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