Immunoreactivity of valosin-containing protein in sporadic amyotrophic lateral sclerosis and in a case of its novel mutant

@inproceedings{Ayaki2014ImmunoreactivityOV,
  title={Immunoreactivity of valosin-containing protein in sporadic amyotrophic lateral sclerosis and in a case of its novel mutant},
  author={Takashi Ayaki and Hidefumi Ito and Hiroko Fukushima and Takeshi Inoue and Takayuki Kondo and Akito Ikemoto and Takeshi Asano and Akemi Shodai and Takuji Fujita and Satoshi Fukui and Hiroyuki Morino and Satoshi Nakano and Hirofumi Kusaka and Hirofumi Yamashita and Masafumi Ihara and Riki Matsumoto and Jun Kawamata and Makoto Urushitani and Hideshi Kawakami and Ryosuke Takahashi},
  booktitle={Acta neuropathologica communications},
  year={2014}
}
BACKGROUND Mutations in the valosin-containing protein (VCP) gene were first found to cause inclusion- body myopathy with early-onset Paget disease and frontotemporal dementia (IBMPFD). Mutations in the VCP gene were later reported to occur in familial amyotrophic lateral sclerosis (ALS). But the role of VCP in the neurodegenerative processes that occur in ALS remains unknown. The purpose of the present study was to elucidate the role of VCP in the neurodegeneration seen in sporadic and VCP… CONTINUE READING
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Journal of neuropathology and experimental neurology • 2007
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