Immunoreactivity of the phosphorylated axonal neurofilament H subunit (pNF-H) in blood of ALS model rodents and ALS patients: evaluation of blood pNF-H as a potential ALS biomarker.

@article{Boylan2009ImmunoreactivityOT,
  title={Immunoreactivity of the phosphorylated axonal neurofilament H subunit (pNF-H) in blood of ALS model rodents and ALS patients: evaluation of blood pNF-H as a potential ALS biomarker.},
  author={Kevin B. Boylan and Cui Hong Yang and Julia Crook and Karen Overstreet and M Elizabeth Heckman and Yong Wang and David Borchelt and Gerry Shaw},
  journal={Journal of neurochemistry},
  year={2009},
  volume={111 5},
  pages={1182-91}
}
Levels of neurofilament subunits, potential biomarkers of motor axon breakdown, are increased in amyotrophic lateral sclerosis (ALS) patient's CSF but data on blood are not available. We measured blood levels of the phosphorylated axonal form of neurofilament H (pNF-H) by ELISA in transgenic rodent models of superoxide dismutase 1 (SOD1) ALS, and in 20 ALS patients and 20 similar aged controls monthly for 4 months. All symptomatic rodent ALS models showed robust levels of blood pNF-H, while… CONTINUE READING

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