Immunoreactivity of proliferating cell nuclear antigen compared with bromodeoxyuridine incorporation in normal and neoplastic rat tissue.

@article{Wijsman1992ImmunoreactivityOP,
  title={Immunoreactivity of proliferating cell nuclear antigen compared with bromodeoxyuridine incorporation in normal and neoplastic rat tissue.},
  author={Jan H. Wijsman and Jan Hein van Dierendonck and Rob Keijzer and Cornelius J H van de Velde and Cees J. Cornelisse},
  journal={The Journal of pathology},
  year={1992},
  volume={168 1},
  pages={75-83}
}
Monoclonal antibodies (MoAbs) against proliferating cell nuclear antigen (PCNA) represent a potentially useful tool for cell kinetic analysis of tumours. Because in paraffin-embedded tissue the relationship between PCNA immunoreactivity and tumour cell proliferation is not well characterized, we have compared PCNA positivity as detected by the PC10 MoAb with the bromodeoxyuridine labelling index (BrdUrd-LI) in two different transplantable hormone-dependent rat mammary tumours. Together, these… CONTINUE READING

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