Immunoreactivity of organic mimeotopes of the E2 component of pyruvate dehydrogenase: connecting xenobiotics with primary biliary cirrhosis.

Abstract

In primary biliary cirrhosis (PBC), the major autoepitope recognized by both T and B cells is the inner lipoyl domain of the E2 component of pyruvate dehydrogenase. To address the hypothesis that PBC is induced by xenobiotic exposure, we took advantage of ab initio quantum chemistry and synthesized the inner lipoyl domain of E2 component of pyruvate… (More)

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Cite this paper

@article{Long2001ImmunoreactivityOO, title={Immunoreactivity of organic mimeotopes of the E2 component of pyruvate dehydrogenase: connecting xenobiotics with primary biliary cirrhosis.}, author={Scott Long and Chao Quan and Judy A Van de Water and Michael H Nantz and Mark J Kurth and Daniel Barsky and Michael E. Colvin and Kit Lam and Ross L. Coppel and A A Ansari and M Eric Gershwin}, journal={Journal of immunology}, year={2001}, volume={167 5}, pages={2956-63} }