Immunoreactivity of beta-amyloid precursor protein in amyotrophic lateral sclerosis.

  title={Immunoreactivity of beta-amyloid precursor protein in amyotrophic lateral sclerosis.},
  author={Shoichi Sasaki and M. Iwata},
  journal={Acta neuropathologica},
  volume={97 5},
We investigated the localization and extent of beta-amyloid precursor protein (beta-APP695) immunoreactivity as a sensitive marker for impairment of fast axonal transport in the spinal cords of 21 patients with amyotrophic lateral sclerosis (ALS), paying special attention to anterior horn neurons. Specimens from 18 patients without neurological disease served as controls. Increased beta-APP immunoreactivity was frequently recognized in the anterior horns of the ALS patients with short clinical… CONTINUE READING


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