Immunoreactivity of an antibody to a beta/A4 sequence with Alzheimer paired helical filaments and tau protein.

@article{Caputo1992ImmunoreactivityOA,
  title={Immunoreactivity of an antibody to a beta/A4 sequence with Alzheimer paired helical filaments and tau protein.},
  author={Chuck Caputo and C. William Scott and Wendel Brunner},
  journal={Alzheimer disease and associated disorders},
  year={1992},
  volume={6 4},
  pages={225-35}
}
beta/A4, a peptide that forms the extracellular amyloid fibrils of Alzheimer senile plaques, has also been proposed to be a component of Alzheimer paired helical filaments (PHFs). We compared BR88, an antiserum to amino acids 1-12 of beta/A4, with BR126, an antiserum to the sequence SEKLDFKDRVQS in tau protein, since tau protein is the only confirmed… CONTINUE READING