Immunoreactivity for neuronal NOS and fluorescent indication of NO formation in the NTS of juvenile rats submitted to chronic intermittent hypoxia.

@article{Pajolla2009ImmunoreactivityFN,
  title={Immunoreactivity for neuronal NOS and fluorescent indication of NO formation in the NTS of juvenile rats submitted to chronic intermittent hypoxia.},
  author={Gisela Pugliesi Pajolla and Daniela Accorsi-Mendonça and Claure Nain Lunardi and Lusiane Maria Bendhack and Benedito H Machado and Ida J Llewellyn-Smith},
  journal={Autonomic neuroscience : basic & clinical},
  year={2009},
  volume={148 1-2},
  pages={55-62}
}
Exposure to chronic intermittent hypoxia (CIH) leads to significant autonomic and respiratory changes, similar to those observed in obstructive sleep apnea. The hypertension associated with CIH is due to sympathoexcitation triggered by long-term exposure to intermittent hypoxia. However, the mechanisms underlying these effects are unknown. Changes in central regulation of sympathetic activity may underlie CIH-induced hypertension. Since NO appears to be mainly sympathoinhibitory in the nucleus… CONTINUE READING