Immunoreactivity for brain‐fatty acid binding protein in gomori‐positive astrocytes

@article{Young1996ImmunoreactivityFB,
  title={Immunoreactivity for brain‐fatty acid binding protein in gomori‐positive astrocytes},
  author={John K. Young and James H. Baker and Thomas M{\"u}ller},
  journal={Glia},
  year={1996},
  volume={16}
}
Gomori‐positive (GP) astrocytes are a subset of brain astrocytes with highly stained cytoplasmic granules that arise from the degradation of mitochondria. The GP granules of these astrocytes are most prominent in the arcuate nucleus of the hypothalamus, but can also be detected in the olfactory bulbs, hippocampus, habenula, and other selected brain regions. The cause and functional effects of this mitochondrial pathology in these glia are not yet known with certainty. 

GLUT2 Immunoreactivity in Gomori-positive Astrocytes of the Hypothalamus

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The possibility that Gomori-positive astrocytes may have an important influence upon the reactivity of the hypothalamus to glucose and that a specialized glucose metabolism may in part underlie the development of mitochondrial abnormalities in hypothalamic GP astroCytes is supported.

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Fatty acid-binding proteins of nervous tissue

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An unusual subset of hippocampal astrocytes makes a fundamental contribution to all three of these hippocampal features and allows different and seemingly conflicting risk factors for AD to be viewed in a unified manner.

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The brain response to 2-deoxy glucose is blocked by a glial drug

Astrocytes in the arcuate nucleus and median eminence that take up a fluorescent dye from the circulation express leptin receptors and neuropeptide Y Y1 receptors

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References

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Composition of Gomori‐positive inclusions in astrocytes of the hypothalamic arcuate nucleus

Evidence, derived from cultured astrocytes, suggests that Gomori‐positive inclusions may consist of autophagocytized accumulations of altered mitochondria and that the peroxidase activity is generated by iron or other metals which accumulate in these mitochondria.

Glial immunoreactivity for metallothionein in the rat brain

A series of frozen and vibratome coronal sections of the rat brain were examined by immunocytochemistry for the presence of a cysteine‐rich metal binding protein, metallothionein, which represented a subset of MT‐positive astrocytes that may be involved in reactions to blood‐borne metal compounds that penetrate into circumventricular organs of the brain.

Association of iron‐containing astrocytes with dopaminergic neurons of the arcuate nucleus

Close contact between TH + neurons and processes of iron‐rich glia was confirmed and suggests a functional relationship between the two cell types that may be related to unusual histochemical features of both cell types and/or to the location of these cells in an area with a highly permeable blood‐brain barrier.

Identification of Gomori‐positive glia in autoradiographs

It is suggested that this positive chemographic effect can be employed for the identification and characterization of Gomori‐positive glia in autoradiographic studies.

Cysteamine Gliopathy in situ: A Cellular Stress Model for the Biogenesis of Astrocytic Inclusions

Systemic cysteamine administration over a 3 week period induced HSP27, 72, 90, and GRP94 (stress proteins) in astrocytes and significantly increased numbers of peroxidase-positive astro cytoplasmic inclusions in the various brain regions relative to controls, indicating that cellular stress may be a very proximal event in the biogenesis of theAstrocytic inclusions.