Immunoreactivity for brain‐fatty acid binding protein in gomori‐positive astrocytes

  title={Immunoreactivity for brain‐fatty acid binding protein in gomori‐positive astrocytes},
  author={John K. Young and James H. Baker and Thomas M{\"u}ller},
Gomori‐positive (GP) astrocytes are a subset of brain astrocytes with highly stained cytoplasmic granules that arise from the degradation of mitochondria. The GP granules of these astrocytes are most prominent in the arcuate nucleus of the hypothalamus, but can also be detected in the olfactory bulbs, hippocampus, habenula, and other selected brain regions. The cause and functional effects of this mitochondrial pathology in these glia are not yet known with certainty. 

Astrocyte fatty acid binding protein‐7 is a marker for neurogenic niches in the rat hippocampus

In rat brains, FABP7+ astrocytes were particularly abundant in the dentate gyrus of the hippocampus and were frequently close to dividing cells immunoreactive for Ki67 protein, suggesting that regional accumulations of FABp7+ Astrocytes may represent reservoirs of cells having the potential for neurogenesis.

Anatomical relationship between specialized astrocytes and leptin‐sensitive neurones

An anatomical basis is provided for the possibility that specialized arcuate astrocytes regulate the function of leptin‐sensitive, feeding‐regulating neurones of the arcuate nucleus.

Physiology of Astroglia.

Astrocytes are tightly integrated into neural networks and act within the context of neural tissue; astrocytes control homeostasis of the CNS at all levels of organization from molecular to the whole organ.

FABP7 upregulation induces a neurotoxic phenotype in astrocytes

The data show that FABP7 overexpression directly promotes an NF‐κB‐driven pro‐inflammatory response in nontransgenic astrocytes that ultimately is detrimental for motor neuron survival and identifies FABp7 as a potential therapeutic target to preventAstrocyte‐mediated motor neuron toxicity in ALS.

Hippocampal Astrocytes and Alzheimer's Disease.

  • J. Young
  • Biology
    The journal of prevention of Alzheimer's disease
  • 2014
An unusual subset of hippocampal astrocytes makes a fundamental contribution to all three of these hippocampal features and allows different and seemingly conflicting risk factors for AD to be viewed in a unified manner.

The brain response to 2-deoxy glucose is blocked by a glial drug

Astrocytes in the arcuate nucleus and median eminence that take up a fluorescent dye from the circulation express leptin receptors and neuropeptide Y Y1 receptors

Hydroxystilbamidine demonstrates that astrocytes take up molecules from the circulation in the median eminence and adjacent arcuate nucleus, and may have a significant signalling role in regulation of food intake.

Neurogenesis Makes a Crucial Contribution to the Neuropathology of Alzheimer’s Disease

  • John K. Young
  • Biology, Psychology
    Journal of Alzheimer's disease reports
  • 2020
Retrograde degeneration of neurons with axons terminating in the dentate gyrus provides a likely explanation for the spatial patterns of neuronal cell death seen in AD.



Composition of Gomori‐positive inclusions in astrocytes of the hypothalamic arcuate nucleus

Evidence, derived from cultured astrocytes, suggests that Gomori‐positive inclusions may consist of autophagocytized accumulations of altered mitochondria and that the peroxidase activity is generated by iron or other metals which accumulate in these mitochondria.

Glial immunoreactivity for metallothionein in the rat brain

A series of frozen and vibratome coronal sections of the rat brain were examined by immunocytochemistry for the presence of a cysteine‐rich metal binding protein, metallothionein, which represented a subset of MT‐positive astrocytes that may be involved in reactions to blood‐borne metal compounds that penetrate into circumventricular organs of the brain.

Association of iron‐containing astrocytes with dopaminergic neurons of the arcuate nucleus

Close contact between TH + neurons and processes of iron‐rich glia was confirmed and suggests a functional relationship between the two cell types that may be related to unusual histochemical features of both cell types and/or to the location of these cells in an area with a highly permeable blood‐brain barrier.

Identification of Gomori‐positive glia in autoradiographs

It is suggested that this positive chemographic effect can be employed for the identification and characterization of Gomori‐positive glia in autoradiographic studies.

Cysteamine Gliopathy in situ: A Cellular Stress Model for the Biogenesis of Astrocytic Inclusions

Systemic cysteamine administration over a 3 week period induced HSP27, 72, 90, and GRP94 (stress proteins) in astrocytes and significantly increased numbers of peroxidase-positive astro cytoplasmic inclusions in the various brain regions relative to controls, indicating that cellular stress may be a very proximal event in the biogenesis of theAstrocytic inclusions.