Immunoreactivity for bcl-2 protein in cutaneous lymphomas and lymphoid hyperplasias.

@article{Triscott1995ImmunoreactivityFB,
  title={Immunoreactivity for bcl-2 protein in cutaneous lymphomas and lymphoid hyperplasias.},
  author={Joe Triscott and Jon H. Ritter and Paul E. Swanson and Mark R. Wick},
  journal={Journal of cutaneous pathology},
  year={1995},
  volume={22 1},
  pages={2-10}
}
The B-cell leukemia/lymphoma gene (bcl-2) produces a unique protein product (BCLP) that is believed to protect lymphoid cells from apoptosis. The bcl-2 gene is frequently rearranged in nodal follicular lymphomas as well as in diffuse lymphoproliferations, but has generally been regarded as most useful in the recognition of the former of these lesions. However, little is known regarding BCLP expression in cutaneous lymphoid infiltrates. Using an immunohistochemical technique and a monoclonal… CONTINUE READING