Immunoreactive endothelin in bronchial biopsy specimens: increased expression in asthma and modulation by corticosteroid therapy.


BACKGROUND The human endothelin (ET) family comprises three 21-amino-acid peptides, which are potent bronchoconstrictors and have a number of other biologic properties relevant to the pathophysiology of asthma. OBJECTIVE We sought to compare the expression of immunoreactive ET in bronchial biopsy specimens from subjects with asthma treated only with… (More)