Immunoreactive corticotropin-releasing hormone and its binding sites in the rat ovary.

  title={Immunoreactive corticotropin-releasing hormone and its binding sites in the rat ovary.},
  author={George P Mastorakos and Elizabeth L. Webster and Theodore C Friedman and George P. Chrousos},
  journal={The Journal of clinical investigation},
  volume={92 2},
Corticotropin-releasing hormone (CRH), the principal neuropeptide regulator of pituitary ACTH secretion, is also produced at peripheral inflammatory sites, where it acts as a proinflammatory cytokine, and by the Leydig cell of the testis, where it exerts autocrine inhibition of testosterone biosynthesis. Because key ovarian functions, such as ovulation and luteolysis, represent aseptic inflammatory responses, and because the theca cell is the functional equivalent of the Leydig cell, we… CONTINUE READING


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