Immunoreactive brain natriuretic peptide in human adrenal glands and adrenal tumors.

@article{Totsune1996ImmunoreactiveBN,
  title={Immunoreactive brain natriuretic peptide in human adrenal glands and adrenal tumors.},
  author={Kazuhito Totsune and Kazuhiro Takahashi and Osamu Murakami and Fumitoshi Satoh and Masahiko Sone and Makoto Ohneda and Yukio Miura and Toraichi Mouri},
  journal={European journal of endocrinology},
  year={1996},
  volume={135 3},
  pages={
          352-6
        }
}
The presence of brain natriuretic peptide (BNP) in tissues of human adrenal glands and adrenal tumors was investigated by radioimmunoassay. Immunoreactive BNP concentrations were 0.203 +/- 0.061 pmol/g wet tissue (mean +/- SEM) in normal parts of adrenal glands (cortex and medulla, N = 8), 0.205 +/- 0.037 pmol/g wet tissue in pheochromocytomas (N = 8), 0.230 +/- 0.062 pmol/g wet tissue in aldosteronomas (N = 11) and 0.180 +/- 0.054 pmol/g wet tissue in adrenocortical adenomas with Cushing's… Expand
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Immunoreactive C-type natriuretic peptide in human adrenal glands and adrenal tumors
TLDR
It is shown that IR-CNP is present in human adrenal glands and adrenal tumors with similar molecular forms and comparable concentrations to those in the human brain. Expand
Brain natriuretic peptide is synthesized in the human adrenal medulla and its messenger ribonucleic acid expression along with that of atrial natriuretic peptide are enhanced in patients with primary aldosteronism.
TLDR
The results are the first to indicate that BNP is synthesized in the human adrenal medulla, and that such medullary BNP synthesis increases in patients with primary aldosteronism, and support the proposal that adrenomedullARY BNP along with ANP may play some role in water and electrolyte homeostasis or act in a paracrine manner to regulate adrenocortical functions. Expand
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TLDR
High performance-gel permeation chromatography and reverse phase-high performance liquid chromatography coupled with the RIA revealed that rat BNP with 45 amino acids is a major storage form as well as a secretory form of rat B NP-LI in the heart, suggesting the presence of complicated diversity of the natriuretic peptide system. Expand
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TLDR
The observations suggest that brain natriuretic peptide dose may not function as a neuropeptide but that it may be a cardiac natriUREtic hormone important in human physiology, involved in the balance of water and electrolytes. Expand
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TLDR
Findings indicate that these three natriuretic peptides are present in the human kidney and raise the possibility that they form a renal natriUREtic peptide system that participates in the local regulation of sodium and water transport and renal circulation in thehuman kidney. Expand
Urinary immunoreactive brain natriuretic peptide in patients with renal disease
TLDR
It is indicated that 24-h urinary excretion of immunoreactive human BNP is increased in patients with renal dysfunction and consists of multiple components, i.e., human B NP-32 itself or a substance very similar to it, smaller molecular forms which are probably metabolic products ofhuman BNP-32, and larger molecular forms. Expand
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It is demonstrated that the lack of inhibitory effect of alpha-hANP on cultured aldosterone-producing adenoma (APA) cells was due to the decrease of ANP-specific receptor, which caused the loss of suppression of ald testosterone and an increase in intracellular cGMP. Expand
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TLDR
Data suggest differential expression of the two natriuretic peptide genes in cardiac and extracardiac tissues in man and the presence of local synthesis of ANP and BNP in various peripheral organs suggests paracrine and/or autocrine function of these natriUREtic peptides. Expand
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TLDR
The first demonstration of an Aldosterone Secretion Inhibitory Factor (ASIF) in acid extracts of bovine adrenal medulla is reported, which might correspond to the endogenous ligand for the receptor sites that were previously identified with [125I]ANF in bovines adrenal cortex and could contribute to the formerly reported attenuating influence of the adrenalmedulla on mineralocorticoid production. Expand
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It is suggested that human brain natriuretic peptide is present in the human brain mainly as larger molecular weight forms. Expand
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