Immunoproteomics: From biomarker discovery to diagnostic applications.

  title={Immunoproteomics: From biomarker discovery to diagnostic applications.},
  author={Harold 4 Tjalsma and Ren{\'e}e M J Schaeps and Dorine W Swinkels},
  journal={Proteomics. Clinical applications},
  volume={2 2},
Circulating antibodies reflect a molecular imprint of antigens that are related to autoimmune diseases, cancer or infection. Importantly, serum antibodies are useful clinical markers as they carry diagnostic information from all around the human body. Moreover, the amplification cascade governed by the humoral immune system causes a surplus of circulating antibodies after appearance of the corresponding (low abundance) antigen. In combination with the fact that antibodies are highly stable… CONTINUE READING