Immunoproteomic analysis to identify Shiga toxin-producing Escherichia coli outer membrane proteins expressed during human infection.

@article{Montero2014ImmunoproteomicAT,
  title={Immunoproteomic analysis to identify Shiga toxin-producing Escherichia coli outer membrane proteins expressed during human infection.},
  author={David Arturo Montero and Paz Orellana and Daniela Sarmiento Guti{\'e}rrez and Daniela V. Araya and Juan P. Salazar and Val{\'e}ria Maria Prado and Angel O{\~n}ate and Felipe Del Canto and Roberto Vidal},
  journal={Infection and immunity},
  year={2014},
  volume={82 11},
  pages={
          4767-77
        }
}
Shiga-toxin producing Escherichia coli (STEC) is the etiologic agent of acute diarrhea, dysentery, and hemolytic-uremic syndrome (HUS). There is no approved vaccine for STEC infection in humans, and antibiotic use is contraindicated, as it promotes Shiga toxin production. In order to identify STEC-associated antigens and immunogenic proteins, outer membrane proteins (OMPs) were extracted from STEC O26:H11, O103, O113:H21, and O157:H7 strains, and commensal E. coli strain HS was used as a… CONTINUE READING

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