Immunoprotection against systemic candidiasis in mice.

@article{Tavares1995ImmunoprotectionAS,
  title={Immunoprotection against systemic candidiasis in mice.},
  author={Delfina Tavares and Paula Ferreira and Manuel Vilanova and A. L. L. Videira and M{\'a}rio Arala-Chaves},
  journal={International immunology},
  year={1995},
  volume={7 5},
  pages={785-96}
}
We have previously described an immunosuppressive B cell mitogenic (ISM) protein, p43, produced by Candida albicans, which plays an important role in the survival of the microorganism in the host. The N-terminal amino acid sequence of p43 was found to be different from all amino acid sequences registered in updated protein databanks. Immunization of BALB/c mice with p43 partially neutralized the biological effects of this protein, namely depletion of bone marrow pre-B and B cells, the increased… CONTINUE READING

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Bone MarrowSibling in part ofSpleen
Immunization of BALB / c mice with p43 partially neutralized the biological effects of this protein , namely depletion of bone marrow pre - B and B cells , the increased numbers of total and large B and CD4 + lymphocytes , and the non - specific polyclonal response of splenic IgG2a- , IgG2b- and IgM - secreting plaque forming cells .
SpleenSibling in part ofBone Marrow
Immunization of BALB / c mice with p43 partially neutralized the biological effects of this protein , namely depletion of bone marrow pre - B and B cells , the increased numbers of total and large B and CD4 + lymphocytes , and the non - specific polyclonal response of splenic IgG2a- , IgG2b- and IgM - secreting plaque forming cells .
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