Immunoprofile of c-MET/PI3K signaling in human salivary gland tumors.

  title={Immunoprofile of c-MET/PI3K signaling in human salivary gland tumors.},
  author={Artur Cunha Vasconcelos and Vivian P Wagner and Lu{\'i}se Meurer and Pablo Agustin Vargas and L{\'e}lia Batista de Souza and Felipe Paiva Fonseca and Cristiane Helena Squarize and Rogerio Moraes Castilho and Manoela Domingues Martins},
  journal={Oral surgery, oral medicine, oral pathology and oral radiology},
  volume={120 2},
OBJECTIVE The aim of this study was to analyze the expression pattern of proteins in the HGF/c-MET/PI3K signaling pathway in salivary gland tumors (SGTs) and to correlate the findings with the proliferative index and clinical parameters. STUDY DESIGN We assembled tissue microarrays (TMAs) of 108 cases of SGTs, including 69 cases of pleomorphic adenoma (PA), 24 cases of adenoid cystic carcinoma (AdCC), and 15 cases of mucoepidermoid carcinoma (MEC). An immunohistochemical analysis of… CONTINUE READING