Immunoprivileged status of the liver is controlled by Toll-like receptor 3 signaling.

  title={Immunoprivileged status of the liver is controlled by Toll-like receptor 3 signaling.},
  author={Karl S Lang and Panco Georgiev and Mike Recher and Alexander Navarini and Andreas Bergthaler and Mathias Heikenwalder and N. Lindsay Harris and Tobias Junt and Bernhard M Odermatt and Pierre-Alain Clavien and Hanspeter Pircher and Shizuo Akira and Hans Hengartner and Rolf Martin Zinkernagel},
  journal={The Journal of clinical investigation},
  volume={116 9},
The liver is known to be a classical immunoprivileged site with a relatively high resistance against immune responses. Here we demonstrate that highly activated liver-specific effector CD8+ T cells alone were not sufficient to trigger immune destruction of the liver in mice. Only additional innate immune signals orchestrated by TLR3 provoked liver damage. While TLR3 activation did not directly alter liver-specific CD8+ T cell function, it induced IFN-alpha and TNF-alpha release. These cytokines… CONTINUE READING
70 Citations
38 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 70 extracted citations


Publications referenced by this paper.
Showing 1-10 of 38 references

Regulatory T cell - mediated transplantation tolerance

  • S. Frigerio
  • Immunol . Res .
  • 2005

Similar Papers

Loading similar papers…