Immunophotodiagnosis of colon carcinomas in patients injected with fluoresceinated chimeric antibodies against carcinoembryonic antigen.

@article{Folli1992ImmunophotodiagnosisOC,
  title={Immunophotodiagnosis of colon carcinomas in patients injected with fluoresceinated chimeric antibodies against carcinoembryonic antigen.},
  author={S Folli and Georges Wagni{\`e}res and Andr{\'e} Pelegrin and J M Calm{\`e}s and D R Braichotte and Franz Buchegger and Y Chalandon and N. Hardman and Christoph H. Heusser and Jean C Givel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 17},
  pages={7973-7}
}
Based on previous experiments in nude mice, showing that fluoresceinated monoclonal antibodies against carcinoembryonic antigen localized specifically in human carcinoma xenografts and could be detected by laser-induced fluorescence, we performed a feasibility study to determine whether this immunophotodiagnosis method could be applied in the clinic. Six patients, with known primary colorectal carcinoma, received an i.v. injection of 4.5 or 9 mg of mouse-human chimeric anti-carcinoembryonic… CONTINUE READING
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