Immunophilins control T lymphocyte adhesion and migration by regulating CrkII binding to C3G.

@article{Nath2014ImmunophilinsCT,
  title={Immunophilins control T lymphocyte adhesion and migration by regulating CrkII binding to C3G.},
  author={Pulak Ranjan Nath and Guangyu Dong and Alex Braiman and Noah Isakov},
  journal={Journal of immunology},
  year={2014},
  volume={193 8},
  pages={3966-77}
}
Crk adaptor proteins are key players in signal transduction from a variety of cell surface receptors. CrkI and CrkII, the two alternative spliced forms of CRK, possess an N-terminal Src homology 2 domain, followed by a Src homology 3 (SH3) domain, whereas CrkII possesses in addition a C-terminal linker region plus a SH3 domain, which operate as regulatory moieties. In this study, we investigated the ability of immunophilins, which function as peptidyl-prolyl isomerases, to regulate Crk proteins… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 2 times. VIEW TWEETS

Similar Papers

Loading similar papers…