Immunophilins and cardiovascular complications.

  title={Immunophilins and cardiovascular complications.},
  author={Eva Mar{\'i}a Calder{\'o}n-S{\'a}nchez and Mar{\'i}a Rodr{\'i}guez-Moyano and Tarik Smani},
  journal={Current medicinal chemistry},
  volume={18 35},
Immunophilins belong to a highly conserved family of proteins with cis-trans peptidyl-prolyl isomerase activity, generally classified by their ability to selectively bind specific immunosuppressive drugs, thereby regulating their activity. Immunophilins include Cyclophilins (CyPs), which are specific targets of the immunosuppressant drug cyclosporin A (CsA); FKBPs (FK506-binding proteins), that are sensitive to both FK506 (tacrolimus) and rapamycin (sirolimus); and FCBPs which are sensitive to… CONTINUE READING