Immunophilins: switched on protein binding domains?

  title={Immunophilins: switched on protein binding domains?},
  author={Michael T G Ivery},
  journal={Medicinal research reviews},
  volume={20 6},
Peptidylprolyl isomerases (PPIases) are a group of cytosolic enzymes first characterized by their ability to catalyze the cis-trans isomerization of cis-peptidylprolyl bonds. Subsequently, some PPIases were also identified as the initial targets of the immunosuppressant drugs-cyclosporin A (CsA), FK506, and rapamycin-have been called immunophilins. Immunophilins have been found to be both widely distributed and abundantly expressed leading to suggestions that they may play a general role in… CONTINUE READING