Immunophenotyping investigation of minimal residual disease is a useful approach for predicting relapse in acute myeloid leukemia patients.

@article{Miguel1997ImmunophenotypingIO,
  title={Immunophenotyping investigation of minimal residual disease is a useful approach for predicting relapse in acute myeloid leukemia patients.},
  author={Jes{\'u}s Fernando San Miguel and Antonio Mart{\'i}nez and Aisha Macedo and Mar{\'i}a Bel{\'e}n Vidriales and Consuelo L{\'o}pez-Berges and Marcos Gonzalez and Dolores D Caballero and Mar{\'i}a Antonia Garc{\'i}a-Marcos and Fernando Ramos and Javier Fern{\'a}ndez-Calvo and Maria Jose Calmuntia and Joaqu{\'i}n D{\'i}az-Mediavilla and Alberto Orfao},
  journal={Blood},
  year={1997},
  volume={90 6},
  pages={2465-70}
}
A high complete remission rate is currently achieved in patients with acute myeloid leukemia (AML). However, many patients eventually relapse due to the persistence of low numbers of residual leukemic cells that are undetectable by conventional cytomorphologic criteria (minimal residual disease [MRD]). Using immunophenotypic multiparametric flow cytometry, we have investigated in sequential studies (diagnosis and follow-up) the impact of MRD detection on the outcome of 53 AML patients that had… CONTINUE READING
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