Immunophenotypic peculiarities of mobilized stem (CD34+) cells in blood from patients with severe spinal cord injury.

Abstract

Immunophenotype of mobilized stem blood cells (CD34+) was studied in 29 patients with late post-traumatic spinal lesions. The CD34+ cells demonstrated different levels of expression of CD45, CD38, monomorphic determinants HLA-DR and gp130 epitopes. Most patients presented with a CD34+ cell fraction with no or low expression of common leukocytic antigen CD45. Only 2 patients had greater than 15 percent of HLA-DR-CD38- cells in the CD34+ fraction. A common transducer molecule of interleukin-6 family cytokines gp130 was expressed on stem (CD34+) cells in all the cases, 26 percent of the patients had an activated gp130 phenotype, i.e. a combination of C7+ and A1- epitopes.

Cite this paper

@article{Tupitsyn2006ImmunophenotypicPO, title={Immunophenotypic peculiarities of mobilized stem (CD34+) cells in blood from patients with severe spinal cord injury.}, author={Nikolay N. Tupitsyn and V N Yaryghin and A S Bryukhovetskiy and L Yu Grivtsova and George Mentkevich and Igor Dolgopolov and A . Yu . Zaitsev and Michail Davydov}, journal={Journal of biological regulators and homeostatic agents}, year={2006}, volume={20 1-2}, pages={36-40} }