Immunophenotypic features of MELF pattern invasion in endometrial adenocarcinoma: evidence for epithelial-mesenchymal transition.

@article{Stewart2009ImmunophenotypicFO,
  title={Immunophenotypic features of MELF pattern invasion in endometrial adenocarcinoma: evidence for epithelial-mesenchymal transition.},
  author={Colin J R Stewart and Leonie Little},
  journal={Histopathology},
  year={2009},
  volume={55 1},
  pages={91-101}
}
AIMS Endometrial endometrioid adenocarcinomas (EEC) may show a distinctive morphological alteration characterized by the presence of microcystic, elongated and fragmented ('MELF') glands. These changes share features of epithelial-mesenchymal transition (EMT) in carcinomas arising at other sites. The aim was to compare the immunophenotypic profile of MELF-type epithelium with conventional glandular areas of EEC. METHODS AND RESULTS Twenty-one EEC were stained immunohistochemically for… CONTINUE READING

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