Immunophenotype of acute myeloid leukemia with NPM mutations: prognostic impact of the leukemic compartment size.

@article{Nomdedu2011ImmunophenotypeOA,
  title={Immunophenotype of acute myeloid leukemia with NPM mutations: prognostic impact of the leukemic compartment size.},
  author={Josep F Nomded{\'e}u and Elena Bussaglia and Neus Villamor and Carmen Victoria P{\'e}rez Mart{\'i}nez and Jordi Esteve and Mar Tormo and C Bertrand Estivill and M. Paz Queipo and Ram{\'o}n Camats I Guardia and Maite Carricondo and Montserrat Hoyos and Aurora Viejo Llorente and Jordi Bombard{\'o} Junc{\'a} and M J Fraile Gallart and Almudena Herrero Domingo and Joan Bargay and Miguel E Mascaro and Jose M Moraleda and Lourdes Florensa and J. M. Ribera and David Gallardo and Salut Brunet and Anna M Avent{\'i}n and Jorge Sierra},
  journal={Leukemia research},
  year={2011},
  volume={35 2},
  pages={
          163-8
        }
}
NPM mutations are the most common genetic abnormalities found in non-promyelocytic AML. NPM-positive patients usually show a normal karyotype, a peculiar morphologic appearance with frequent monocytic traits and good prognosis in the absence of an associated FLT3 mutation. This report describes the immunophenotypic and genetic characteristics of a consecutive series of NPM-mutated de novo AML patients enroled in the CETLAM trial. Eighty-three patients were included in the study. Complete… CONTINUE READING
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CD34 expression and the outcome of nucleophosmin 1-mutated acute myeloid leukemia

  • Annals of Hematology
  • 2016
VIEW 3 EXCERPTS
CITES BACKGROUND, METHODS & RESULTS
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References

Publications referenced by this paper.
SHOWING 1-10 OF 36 REFERENCES

Monoclonal antibodymediated targeting of CD 123 , IL3 receptor a chain , eliminates human acute myeloid leukemic stem cell

L Jing, EM Lee, +3 authors L Wilkinson
  • Cell Stem Cell
  • 2009

NPM 1 but not FLT 3ITDmutations predict early blast cell clearance and CR rate in patientswith normal karyotypeAML ( NKAML ) or highriskmyelodysplastic syndrome ( MDS )

F Schneider, E Hoster, +3 authors T Benthaus
  • Blood
  • 2009

NPM 1 but not FLT 3ITDmutations predict early blast cell clearance and CR rate in patientswith normal karyotypeAML ( NKAML ) or highriskmyelodysplastic syndrome ( MDS )

F Schneider, E Hoster, +3 authors T Benthaus
  • Blood
  • 2009

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