Immunopharmacology of the superantigen staphylococcal enterotoxin A in T-cell receptor V beta 3 transgenic mice.

@article{Dohlsten1993ImmunopharmacologyOT,
  title={Immunopharmacology of the superantigen staphylococcal enterotoxin A in T-cell receptor V beta 3 transgenic mice.},
  author={Mikael Dohlsten and Mikael Bj{\"o}rklund and Anette Sundstedt and Gunnar Hedlund and Diana Samson and Terje Kalland},
  journal={Immunology},
  year={1993},
  volume={79 4},
  pages={520-7}
}
The response of mouse T cells to the superantigen staphylococcal enterotoxin A (SEA) requires 1000-fold higher concentrations compared to human T cells. In order to develop a sensitive model for SEA studies in mice, the immunopharmacology has been studied in T-cell receptor (TcR) V beta 3 transgenic (TGV beta 3) and non-transgenic (non-TG) C57Bl/6 mice. The frequency of SEA-responsive T cells in the TGV beta 3 mice exceeded 90%, whereas a 10-fold lower frequency was seen in normal C57Bl/6 mice… CONTINUE READING
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