Immunopharmacology of CpG oligodeoxynucleotides and ribavirin.

  title={Immunopharmacology of CpG oligodeoxynucleotides and ribavirin.},
  author={Joerg Vollmer and Robert A. Rankin and Hanna Hartmann and Marion Jurk and Ulrike Samulowitz and Tanja Wader and Andrea Janosch and Christian Schetter and Arthur M. Krieg},
  journal={Antimicrobial agents and chemotherapy},
  volume={48 6},
To investigate their potential mechanisms of action, the nucleoside analogue ribavirin and a TLR9 agonist were compared. The CpG oligodeoxynucleotides (ODN) demonstrated strong TLR9-related Th1-type effects, and ribavirin appeared only to mediate signaling in TLR-transfected cells. CpG ODN represent a promising new type of therapeutic drug for hepatitis C or other infectious diseases. 
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