Immunopharmacology of CpG oligodeoxynucleotides and ribavirin.


To investigate their potential mechanisms of action, the nucleoside analogue ribavirin and a TLR9 agonist were compared. The CpG oligodeoxynucleotides (ODN) demonstrated strong TLR9-related Th1-type effects, and ribavirin appeared only to mediate signaling in TLR-transfected cells. CpG ODN represent a promising new type of therapeutic drug for hepatitis C… (More)


4 Figures and Tables

Cite this paper

@article{Vollmer2004ImmunopharmacologyOC, title={Immunopharmacology of CpG oligodeoxynucleotides and ribavirin.}, author={J. Vollmer and R. Rankin and Hanna Hartmann and Marion Jurk and Ulrike Samulowitz and Tanja Wader and Andrea Janosch and Christian Schetter and Arthur M. Krieg}, journal={Antimicrobial agents and chemotherapy}, year={2004}, volume={48 6}, pages={2314-7} }