Corpus ID: 24579211

Immunopharmacological actions of the new antiallergic drug butyl 3'-(1H-tetrazol-5-yl)oxanilate. 1st communication: effects on type I to type IV allergic reactions in animal models.

@article{Yanagihara1988ImmunopharmacologicalAO,
  title={Immunopharmacological actions of the new antiallergic drug butyl 3'-(1H-tetrazol-5-yl)oxanilate. 1st communication: effects on type I to type IV allergic reactions in animal models.},
  author={Y. Yanagihara and T. Abe and K. Edanami and M. Agata and T. Kuroda and T. Shida},
  journal={Arzneimittel-Forschung},
  year={1988},
  volume={38 1},
  pages={
          70-4
        }
}
The effects of butyl 3'-(1H-tetrazol-5-yl)oxanilate (WP-833), a new antiallergic drug, on type I to type IV allergic reactions were investigated by employing various animal models. WP-833 (i.v. and p.o.) dose-dependently inhibited homologous or heterologous passive cutaneous anaphylaxis (PCA) mediated by rat or mouse immunoglobulin E (IgE) in rats. Homologous PCA caused by guinea pig IgE was also inhibited by WP-833. In addition, WP-833 had inhibitory actions upon homologous PCA induced by rat… Expand
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Tazanolast(WP-833)代謝物の抗アレルギー作用
WP-833の代謝物である3'-(1H-tetrazol-5-y1)oxanilic acid(MTCC),3-(1H-tetrazol-5-yl)aniline(MTA)および3'-(1H-tetrazol-5-yl)acetanilide(MTAA)のラットおよびモルモットhomologous passive cutaneousExpand