Corpus ID: 22370839

Immunopharmacological actions of the new antiallergic drug butyl 3'-(1H-tetrazol-5-yl)oxanilate. 3rd communication: inhibitory effects on histamine release from lung fragments, Schultz-Dale reaction in isolated tracheal muscle and experimental asthma in guinea pigs.

@article{Yanagihara1988ImmunopharmacologicalAO,
  title={Immunopharmacological actions of the new antiallergic drug butyl 3'-(1H-tetrazol-5-yl)oxanilate. 3rd communication: inhibitory effects on histamine release from lung fragments, Schultz-Dale reaction in isolated tracheal muscle and experimental asthma in guinea pigs.},
  author={Y. Yanagihara and T. Abe and T. Kuroda and T. Shida},
  journal={Arzneimittel-Forschung},
  year={1988},
  volume={38 1},
  pages={
          80-3
        }
}
The inhibitory effects of butyl 3'-(1H-tetrazol-5-yl) oxanilate (WP-833), a new antiallergic drug, on histamine release from lung fragments, Schultz-Dale (SD) reaction in isolated tracheal muscle and experimental asthma were investigated in guinea pigs passively sensitized with homologous immunoglobulin E (IgE) serum. WP-833 dose-dependently inhibited antigen-induced histamine release from lung fragments. In addition, synergism as to inhibition of histamine release was observed with a… Expand
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Tazanolast(WP-833)代謝物の抗アレルギー作用
WP-833の代謝物である3'-(1H-tetrazol-5-y1)oxanilic acid(MTCC),3-(1H-tetrazol-5-yl)aniline(MTA)および3'-(1H-tetrazol-5-yl)acetanilide(MTAA)のラットおよびモルモットhomologous passive cutaneousExpand