Corpus ID: 30440236

Immunopharmacologic properties of WY-16, 922, a new orally effective antiallergic agent.

@article{Rosenthale1976ImmunopharmacologicPO,
  title={Immunopharmacologic properties of WY-16, 922, a new orally effective antiallergic agent.},
  author={M. Rosenthale and A. J. Begany and A. Dervinis and J. Sellstedt and C. Guinosso and M. Gluckman},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1976},
  volume={197 3},
  pages={
          725-33
        }
}
  • M. Rosenthale, A. J. Begany, +3 authors M. Gluckman
  • Published 1976
  • Medicine
  • The Journal of pharmacology and experimental therapeutics
  • In a series of tests designed to illustrate immune reactions similar to those obtained in atopic disease, Wy-16,922 effectively inhibited reaginic-mediated immunologic reactions in the skin, lungs and mast cell. It was found to be devoid of immunosuppressant, antimediator, anti-inflammatory, steroid or bronchodilator properties as well as acute toxicity. Although the mechanism of action of Wy-16,922 is unknown, it appears to limit the release (not the effects) of allergic mediators in a manner… CONTINUE READING