Immunopathology of interstitial cystitis.

  title={Immunopathology of interstitial cystitis.},
  author={Jonathan Said and R M van de Velde and L S Gillespie},
  journal={Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc},
  volume={2 6},
This study describes histologic, ultrastructural, and immunofluorescence microscopy findings of cystoscopically directed biopsies of lesional tissue and uninvolved bladder from 308 patients with chronic interstitial cystitis (IC) and no evidence of infection, collagen vascular, or other systemic disease. The majority of cases exhibited strong urothelial cell staining for immunoglobulin A (IgA), which was focal or diffusely involved all layers of the epithelium. Electron microscopy revealed… CONTINUE READING