Immunopathology and human mast cell cytokines.

  title={Immunopathology and human mast cell cytokines.},
  author={Peter Bradding and Stephen T. Holgate},
  journal={Critical reviews in oncology/hematology},
  volume={31 2},
The mast cell is a virtual pharmacopoeia of biological substances. It used to be believed that mast cell activation was all-or-nothing, with IgE cross-linking inducing symptoms of allergy and anaphylaxis. However, the activity of mast cells in health and disease is clearly much more complicated than this. The discovery that human mast cells secrete many pleiotropic cytokines suggested there may be many novel mast cell functions, and many of these are now being realised. The ubiquitous… CONTINUE READING
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