Immunopathologic patterns of cyclosporine deposition associated with nephrotoxicity in renal allograft biopsies.

@article{Kolbeck1987ImmunopathologicPO,
  title={Immunopathologic patterns of cyclosporine deposition associated with nephrotoxicity in renal allograft biopsies.},
  author={Peter C. Kolbeck and John A. Wolfe and J Burchette and Fred Sanfilippo},
  journal={Transplantation},
  year={1987},
  volume={43 2},
  pages={218-24}
}
Using antibody directed against cyclosporine (CsA-Ab) in an avidin-biotin-complex immunoperoxidase technique on routine formalin-fixed tissue specimens, 46 renal biopsies from CsA-treated renal allograft recipients and 23 biopsies from non-CsA-treated patients were examined to identify staining patterns potentially associated with CsA nephrotoxicity (CsA-NT). All specimens were examined independently in a masked fashion by two pathologists for the intensity of (CsA-Ab) specific staining for… CONTINUE READING