Immunopathologic alterations in murine models of sepsis of increasing severity.

  title={Immunopathologic alterations in murine models of sepsis of increasing severity.},
  author={Samuel J. Ebong and Douglas R. Call and Jean A. Nemzek and Gerald L Bolgos and David E. Newcomb and Daniel G Remick},
  journal={Infection and immunity},
  volume={67 12},
We investigated inflammatory and physiologic parameters in sepsis models of increasing lethality induced by cecal ligation and puncture (CLP). Mice received imipenem for antibiotic therapy, and groups were sacrificed at 2, 4, 8, 12, 16, 20, and 24 h after CLP. The severity of sepsis increased with needle puncture size (lethality with 18-gauge puncture [18G], 100%; 21G, 50%; 25G, 5%; sham treatment, 0%). While the temperature (at 12 h) and the activity and diurnal rhythm (at day 4) of the 25G… CONTINUE READING


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